Researcher: Justin Yang
Affiliation: The University of Sydney
Fields of research: Immunology (3204)
Project: Analysis of data for prediction of cancer patient response to checkpoint therapy
This project investigates multi-omic biomarkers that provide robust, reproducible prediction of a cancer patient’s likelihood of responding to immune checkpoint blockade. By integrating bulk RNA-seq and ATAC-seq with flow-cytometric immune subset profiling, we aim to uncover the transcriptomic and epigenetic determinants of primary immunotherapy resistance across lung cancer and melanoma cohorts.
Collaborators and funding
- Collaborators: Chris O’Brien Lifehouse