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BioShell Research: Mapping the co-aggregation proteome of TDP-43 in models of ALS/FTD

Researcher: Anna Harutyunyan

Affiliation: The University of Sydney

Fields of research: Biochemistry and cell biology (3101); Neurosciences (3209); Bioinformatics and computational biology (3102)

Project: Mapping the co-aggregation proteome of TDP-43 in models of ALS/FTD

We aim to understand the molecular and cellular causes of amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) and frontotemporal dementia (FTD). To this end we employ various genetically engineered in vitro and in vivo model systems, advanced microscopy and biochemistry techniques to develop and test potential therapeutics in proof-of-concept pre-clinical studies.

Collaborators and funding

  • Collaborators: Neurodegeneration Pathobiology Group; Charles Perkins Centre, Sydney Pharmacy School and Centre for Drug Discovery and Innovation, The University of Sydney
  • Funding: NHMRC, FightMND